Leading Chitosan Manufacturer: Quality & Quantity Guaranteed

Chitosan, a natural polymer derived from crustacean shells, is fast gaining recognition for its versatility and environmental value. The path from shell waste to high-purity Chitosan is not simply a chemical process; it’s a carefully managed sequence of scientific, operational, and logistical steps, refined by those who believe in the future of sustainable materials. The work behind producing Chitosan for human and industrial use, at a level where both quality and quantity are assured, is a remarkable achievement led by expert chitosan manufacturers that highlights the efficacy of thoughtful leadership and technical mastery.

From an industrial perspective, the challenge has never been only about extraction or purification. The reliability of Chitosan as a functional ingredient—serving roles from food supplements to medical-grade actives—rests on careful control of its chemical characteristics. Variant specifications like deacetylation degree, molecular weight, viscosity, and clean raw material origins all define which Chitosan is suited for a specific market or product.

 

Chitosan product export quality

Beyond Waste: Sourcing Chitosan with Purpose

The shells that once ended up as waste now provide a gateway to high-value materials. Sourcing begins with snow crab and blue crab shells, often straight from the food manufacturing line. These shells are not just plentiful; when processed quickly and under certified conditions, they provide a clean, consistent source of Chitosan.

This is the reason behind the firm’s reliable output—daily fresh raw materials that form the backbone of their operation. At any given moment, the manufacturing lines move anywhere between 3-5 tons of raw shells, ultimately supporting a total annual production capacity reaching 80 tons or more.

 

Shell Source

Attributes

Annual Chitosan Output (MT)

Certifications

Snow Crab

Pristine, large shells

60-80

EU, GMP, HACCP

Blue Crab

Clean, high protein content

Included in above

EU, GMP, HACCP

Shrimp/Squid

Secondary, specialty batches

Variable

EU, GMP, HACCP

 

 



Precision in Production: Defining Chitosan Grades

Different applications require different Chitosan profiles. This is why offering a selection based on deacetylation degree (DD), molecular weight (MW), and viscosity is essential. Each attribute determines how the final product performs in items as varied as medical devices, dietary supplement capsules, biodegradable cutlery, or plant growth stimulants.

Chitosan Specifications Offered

  • Deacetylation Degree (%DD):  more than 90% , 90–80 % , less than 80%
  • Molecular Weight (MW):
    • High MW: >2,000 kDa
    • 2,000–1,000 kDa
    • 1,000–500 kDa
    • 500–200 kDa
    • 200–80 kDa
    • 80–30 kDa
    • Low MW: <30 kDa (down to 10 kDa)
  • Viscosity Range:
    • High: 4,000–2,000 cPs
    • 2,000–1,000 cPs
    • 900–600 cPs
    • 600–300 cPs
    • 300–100 cPs
    • 100–20 cPs
    • Very Low: <10 cPs (~5 cPs)

This kind of range means a customer seeking a food-grade polymer for supplement capsules does not receive the same Chitosan as a company creating water purification beads or bio-agricultural films. The right match maximizes performance and safety.

 

Investment in Quality, Investment in Trust

Chitosan destined for human consumption or pharmaceutical usage faces a higher bar. The materials must meet strict standards, including food and medical device regulations under various international frameworks. This is where certifications such as GMP, HACCP, and EU-compliance make a visible difference.

Every step, from cleaning shells to packaging Chitosan powder, is handled in certified facilities:

      • GMP (Good Manufacturing Practice): Ensures repeatable, documented processes for safety and purity
      • HACCP (Hazard Analysis and Critical Control Points): Focuses on risk management and food safety from start to finish
      • EU compliance: Particularly with Medical Device Regulation (EU) No. 722/2012, guaranteeing animal-borne disease controls

Continuous auditing and process optimization become the running pulse of the operation. There is no shortcut here; clients who depend on consistent, bioactive Chitosan demand this level of oversight.

Building a Specialty: Decades of Expertise

The foundation of a chitosan manufacturer specialist is rarely built overnight. More than 20 years here translates to sustained research, precise process development, and a series of incremental advancements in extraction, purification, and formulation.

Researchers at the facility have not only refined the classic forms of Chitosan but have also developed new derivatives—such as the L112 Biopolymer. These enhanced Chitosan forms showcase the intersection between pure science and industrial practicality, where every improvement in the polymer’s characteristics leads to a measurable difference in its use.

The dedication goes beyond scaling up production:

      • Ongoing investment in state-of-the-art equipment and controlled clean-room environments
      • Rigorous implementation of quality management systems (QMS)
      • Long-term partnerships with food and biotech companies across Asia, North America, and Europe

The team itself is shaped by a blend of scientific academic backgrounds and hands-on manufacturing know-how, united by a belief in making a difference with every batch of Chitosan produced.

 

Meeting Demand: From Factory Floor to Export Pallets

Stability in supply is as important as quality, and it’s this stability that sets apart vendors capable of meeting global industrial demand. The process begins at the seafood line, where shells are diverted fresh to the Chitosan facility. By synchronizing schedules between shell providers and manufacturers, delays are minimized and degradation is avoided—a critical point for product consistency.

From intake to finished powder, safeguards ensure full traceability:

    • Real-time logging of raw material origin and quality
    • Documented process controls for deacetylation and purification
    • Lot-by-lot testing to match spec with customer requirements
    • Coordinated exports in compliance with international trade standards

The end result is a manufacturing line ready to support even the most ambitious of product launches or R&D drives.

 

Applications: Chitosan for People, the Planet, and Industry

What’s striking about Chitosan is how its appeal reaches across categories:

    • Human Consumption:
      • Dietary supplements for weight management and cholesterol control (triglyceride and LDL binding properties)
      • Capsules and tablet binders (food-grade and pharma-grade)
    • Agriculture and Animal Farming:
      • Functional feed additives (FCR reduction, gut health for poultry and swine)
      • Plant growth enhancers and elicitors
    • Water and Wastewater Treatment:
      • Heavy metal chelation
      • Organic pollutant absorption
    • Bioplastics:
      • Packaging, single-use tableware (biodegradable spoons and plates)
    • Medical Devices:
      • Wound care, drug delivery, and advanced filtration

With this breadth, Chitosan has become a platform ingredient—each grade unlocking its own set of possibilities.

 

Research, Development, and the Forward View

What keeps the field of Chitosan moving forward is an active program in research and development, supported by leading chitosan manufacturers. The drive for improved derivatives sees a blending of chemical modification, process enhancement, and feedback from real-world applications.

Recent years have witnessed steps such as:

    • The launch of new, more absorbent L112 grades for animal farming and dietary use
    • Adaptation of extraction and purification for alternative shell sources (like squid pens and shrimp shells)
    • Expansion into collagen production from fish scales, further minimizing waste and broadening market opportunities

To qualify to support the customer's Quality & Quantity

Quantity

Main Chitosan raw material  are snow crab shells and blue crab shells , which made of clean and fresh material. Daily directly from our GMP/HACCP food manufacturing plant, approximately 3-5 tons. Our snow crab shells' Chitosan capacity is stable at more than 60-80 tons per year


Quality

Our collaboration with a GMP/HACCP seafood factory, along with our EU certificates. Ensures that we use only the freshest crab shells from our seafood production GMP/HACCP line to manufacture Chitosan.

We are committed to implementing and maintaining the highest quality systems, including QMS, HACCP, and ISO series with certification.


Bio21's partner from the food processing factory is certified in HACCP and EU. Our Chitin and Chitosan products are produced from high-quality raw materials (snow crab shells) and qualified for use in Chitosan food, medical devices, and pharma.

Our raw material snow crab shells for  Food-grade Chitosan, Medical-device grade Chitosan , and Pharma grade Chitosan are qualified the regulation (EU) no. 722/2012 (Medical Devices risk management and controls to prevent spreading certain animal-borne diseases to users of their products) requirements

Chitosan for human consumption production

We are one of the specialists Chitosan manufacturer

This is from thinking about the world, especially products that help the environment and valuable products for all things, not just humans.


Why did we choose to manufacture Chitosan?

Chitosan, a natural polymer derived from seafood production waste, has the transformative power to turn what was once a 'by-product' into a valuable resource. This potential is truly inspiring.

Chitosan is a natural product; the benefits of Chitosan are not only for human use but beneficial to the environment;

- It is used for wastewater treatment and water treatment for consumer
- Eliciting plants (a natural growth hormone)
- Reduction of FCR (Feed Conversion Rate) in economic animals
- Biodegradable products such as spoons and plates
- Medical devices lower LDL cholesterol and fat-binding (triglyceride) for human or animal farming consumption
, etc


At Bio21, our journey with Chitosan began with a small team. Despite the challenges, we have persevered, never wavering in our commitment to this valuable product. Our unwavering dedication instills confidence in the potential we see in Chitosan.


We have been going step-by-step on research and development for Chitosan products and Chitosan applications products, production line development, raw materials, quality systems, and business partners

Bio21 Chitosan manufacturer
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20

Over 20 years of experience in industrial-scale manufacturing and supplying Chitosan 

Why do we identify BIO21 as a Chitosan manufacturer specialist


Excellent raw material: clean and fresh snow crab shells discarded from the GMP/HACCP food processing line

20 years of production experience on the industrial scale

Quality system; QMS , GMP/HACCP , EU-Certificated

Chitosan products from the research and development

Enhance-Chitosan products; L112 Biopolymer and Chitosan spec L112

Stable in quantity supply; 60-80 MT per year 

Mr. Kasem, Bio21 founder, a specialist Chitosan manufacturer

Mr. Kasem Pansanga
B.Sc Operations Research. Oct. 1991
Ramkhamhaeng University

Mr. Paisan, Bio21 founder, a specialist Chitosan manufacturer

Mr. Paisan Pansanga
M.Sc Chemical Technology. Oct. 1998
Chulalongkorn University

April 2001

It comes from vision, commitment, and a belief in the beneficial effects of Chitosan products on all things, not only humans. We believe in our potential to prove human ability, chemistry, and biotechnology knowledge. We established Aqua Premier (Bannawach Bio-Line) to manufacture Chitosan.

2003 - start from Chitin production

Industrial scale of Chitin production for the raw material of Glocosamne production project

2004- The first factory of Chitin and Chitosan

The first Chtin and Chitosan production plant construction, in proposes for expanding capacity under Bannawach Bio-Line Co.,Ltd.

2005-2008 Chitosan production project

  • A member of the R&D team in part of Chitosan preparation for enhanced Chitosan derivative for a dietary supplement, L112 Biopolymer and Chitosan spec L112 in research and development of;

Optimizing chitosan characteristics for effective use in human weight-loss regimens
Phase I & II study Chitosan of interest
Phase III study: Chitosan of interest in rats

  • Investment in equipment, machinery, lab-room, lab equipment, and clean-room class 100k environment for manufacturing L112 Biopolymer and Chitosan in medical device grade and food grade included implementing the QMS (Quality Management System)
  • Manufacturer Chitosan purpose for export and material to produce L112 Biopolymer
  • Manufacturer L112 Biopolymer export to USA which re-export to EU finished-product wide-popular in EU countries
  • Produce Chitin export to Japan, we have expanded Chitin production capacity to the Indonesia factory

November 2008

  • Mr. Kasem and Mr. Paisan have chosen to walk away from the Bannawach Bio-line factory for shareholder reasons. Then Bio21 was established along with the first strategic planned "we are one of the Specialist Chitosan Manufacturer"
  • Continue research and development in Chitosan and L112 Biopolymer
  • Launch finished-product L112 Absorbital, a natural fiber fat binding tablets and capsule type for a human consumption
  • Continue in Chitosan applications R&D, manufacturing and selling Chitosan and Chitosan applications

2009-2021

2010: Start a new Chitosan factory in Samutsakorn province for marketing and selling proposes in EU, USA Asia markets and Launch New L112 Absorbital and Advance-L112 Absorbital products


2012: Start the food-grade / dietary supplement Chitosan and medical device Chitosan for JAPAN and ASIAN

2013: Launch a new Chitosan application in the agricultural product "FCR additive" for broiler farm by R&D including a test run at the prototype farm (EVAP farm system)


2014: Restart the dietary supplement / medical device Chitosan business with a customer from an EU country

2015: The second Chitosan factory in Banyuwangi Indonesia is ready for production of industrial grade and food grade Chitosan.

2018: Signed the Agreement on quality assurance for Chitosan supplies for EU customer, and started production of fish scale OSSEIN at Indonesia factory, purposes for commercial and in-house used in Collagen production in the future.

2019: Started production of fish scale OSSEIN in Thailand factory and started a pilot scale of fish scale Collagen by using the OEM

2020: Implement and launch L112 Polymer product for Broiler Farming, Poultry Farming (Layer chicken Farming), and Pig Farming

2021: The optimized production capacity of OSSEIN (Decalcified fish scale) products is 240-360 MT per year.

2022-2024 GMP/HACCP Chitosan manufacturing plant

2022: Time to global GMP/HACCP factory

We have started preparing for the future; in 2023 will be the 2nd chance time for the small ways of BIO21 to go global; we are cooperating with the crab meat factory with the HACCP and EU certificate. We use fresh crab shells (almost the snow crab shells) directly from the food processing line to produce CHITIN and CHITOSAN. And it is also time to implement the quality systems QMS, HACCP, EU, and ISO series with certification.


2024: Live the GMP/HACCP Chitosan manufacturing plant

March 2024; the new CHITOSAN production plant ready to production with a capacity approximately 60-80 MT per year